As a certified (or is it certifiable?) Twitter power user I am very finicky when it comes to choosing a Twitter client.
For me, Twitter.com is out of the question. There’s just not enough going on. I have to click around to see my @replies and DMs. No columns? That’s a dealbreaker.
When I’m at my computer and have a Twitter client open I want to be able to easily scan all of my activity. I want to see my @replies, search terms I’m monitoring and DMs easily. Seesmic’s Web App actually goes one step further and has already integrated lists! I can monitor my lists right there in their own little column. It’s enough to make this geek practically giddy.
TweetDeck has been my go to desktop client for quite some time, but with the evolution of Twitter Web Apps I find myself using them more and more even when I’m on my own machine. It’s the same reason I’m such a Gmail fanatic, it’s by far the best web based email out there. Once a web app can compete, or beat a desktop client (for any application) my choice is going to be a web app because I like my experience to be the same no matter where I’m logging in from. It’s why I’m excited to see Seesmic starting to nail this.

